Article
Expression and localisation of the essential copper transporter DmATP7 in Drosophila neuronal and intestinal tissues.
The international journal of biochemistry & cell biology - 1 Jan 2008
Burke Richard, Commons Elizabeth, Camakaris James
Abstract excerpt
Copper homeostasis is achieved by a combination of regulated uptake, efflux and sequestration and is essential for animal health and viability. Transmembrane copper transport proteins of the P-type ATPase family play key roles in cellular copper efflux. Here, the transcriptional and post-translational regulation of DmATP7, the sole Drosophila melanogaster ortholog of the human MNK and WND copper transport genes,...
Topics
- Animals
- Cation Transport Proteins
- Cell Membrane
- Copper
- Copper-Transporting ATPases
- DNA-Binding Proteins
- Drosophila melanogaster
- Enhancer Elements, Genetic
- Gene Expression Regulation
- Genes, Reporter
- Intestinal Mucosa
- Intestines
- Male
- Mutation
- Neurons
- Transcription Factors
- Transcription Factor MTF-1