Article
The homologous putative GTPases Grn1p from fission yeast and the human GNL3L are required for growth and play a role in processing of nucleolar pre-rRNA.
Molecular biology of the cell - 1 Jan 2006
Du Xianming, Rao Malireddi R K Subba, Chen Xue Qin, Wu Wei, Mahalingam Sundarasamy, Balasundaram David
Abstract excerpt
Grn1p from fission yeast and GNL3L from human cells, two putative GTPases from the novel HSR1_MMR1 GTP-binding protein subfamily with circularly permuted G-motifs play a critical role in maintaining normal cell growth. Deletion of Grn1 resulted in a severe growth defect, a marked reduction in mature rRNA species with a concomitant accumulation of the 35S pre-rRNA transcript, and failure to export the ribosomal...
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