Article
Arabidopsis thaliana G3BP Ortholog Rescues Mammalian Stress Granule Phenotype across Kingdoms.
International journal of molecular sciences - 11 Jun 2021
Reuper Hendrik, Götte Benjamin, Williams Lucy, Tan Timothy J C, McInerney Gerald M, Panas Marc D, Krenz Björn
Abstract excerpt
Stress granules (SGs) are dynamic RNA-protein complexes localized in the cytoplasm that rapidly form under stress conditions and disperse when normal conditions are restored. The formation of SGs depends on the Ras-GAP SH3 domain-binding protein (G3BP). Formations, interactions and functions of plant and human SGs are strikingly similar, suggesting a conserved mechanism. However, functional analyses of plant...
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