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Article

Coupled GTPase and remodelling ATPase activities form a checkpoint for ribosome export.

Nature - 2 Jan 2014

Matsuo Yoshitaka, Granneman Sander, Thoms Matthias, Manikas Rizos-Georgios, Tollervey David, Hurt Ed

Abstract excerpt

Eukaryotic ribosomes are assembled by a complex pathway that extends from the nucleolus to the cytoplasm and is powered by many energy-consuming enzymes. Nuclear export is a key, irreversible step in pre-ribosome maturation, but mechanisms underlying the timely acquisition of export competence re...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24240281
DOI: 10.1038/nature12731
PMCID: PMC3880858

Genes

GNL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-24240281-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

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Coupled GTPase and remodelling ATPase activities form a checkpoint for ribosome export.PMID 24240281Read ↗

Mutational Analysis of the Nsa2 N-Terminus Reveals Its Essential Role in Ribosomal 60S Subunit Assembly.Semantic proximity Read ↗

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The AAA ATPase Rix7 powers progression of ribosome biogenesis by stripping Nsa1 from pre-60S particles.Semantic proximity Read ↗

The ribosome assembly factor Nop53 has a structural role in the formation of nuclear pre-60S intermediates, affecting late maturation events.Semantic proximity Read ↗

The putative GTPases Nog1p and Lsg1p are required for 60S ribosomal subunit biogenesis and are localized to the nucleus and cytoplasm, respectively.Semantic proximity Read ↗

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