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Article

Mutations in β-Lactamase AmpC Increase Resistance of Pseudomonas aeruginosa Isolates to Antipseudomonal Cephalosporins.

Antimicrobial agents and chemotherapy - 1 Oct 2015

Berrazeg M, Jeannot K, Ntsogo Enguéné Véronique Yvette, Broutin I, Loeffert S, Fournier D, Plésiat P

Abstract excerpt

Mutation-dependent overproduction of intrinsic β-lactamase AmpC is considered the main cause of resistance of clinical strains of Pseudomonas aeruginosa to antipseudomonal penicillins and cephalosporins. Analysis of 31 AmpC-overproducing clinical isolates exhibiting a greater resistance to ceftazidime than to piperacillin-tazobactam revealed the presence of 17 mutations in the β-lactamase, combined with various...

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Identifiers

PMID: 26248364
DOI: 10.1128/AAC.00825-15
PMCID: PMC4576058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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