Retinoic acid induces cells cultured from oral squamous cell carcinomas to become anti-angiogenic.

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Article

Retinoic acid induces cells cultured from oral squamous cell carcinomas to become anti-angiogenic.

The American journal of pathology - 1 Jul 1996

Lingen M W, Polverini P J, Bouck N P

Abstract excerpt

Retinoids have shown great promise as chemopreventive against the development of squamous cell carcinomas of the upper aerodigestive tract. However, the exact mechanism by which they block new tumors from arising is unknown. Here, we report that 13-cis- and all-trans-retinoic acid, used at clinic...

Topics

Animals
Breast Neoplasms
Carcinoma, Squamous Cell
Colonic Neoplasms
Cornea
Endothelium, Vascular
Female
Fibrosarcoma
Humans
Interleukin-8
Keratinocytes
Neovascularization, Pathologic
Neovascularization, Physiologic
Neutralization Tests
Phenotype
Rats
Rats, Inbred F344
Tongue Neoplasms

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Open in PubMed Open full text

Identifiers

PMID: 8686749
PMCID: PMC1865246

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8686749-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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