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Unchanged NADPH Oxidase Activity in Nox1-Nox2-Nox4 Triple Knockout Mice: What Do NADPH-Stimulated Chemiluminescence Assays Really Detect?

Antioxidants & redox signaling - 1 Mar 2016

Rezende Flávia, Löwe Oliver, Helfinger Valeska, Prior Kim-Kristin, Walter Maria, Zukunft Sven, Fleming Ingrid, Weissmann Norbert, Brandes Ralf P, Schröder Katrin

Abstract excerpt

NADPH oxidases of the Nox family are considered important sources of cellular reactive oxygen species (ROS) production. This conclusion is, in part, based on the ability of NADPH to elicit a chemiluminescence signal in tissue/cell homogenates or membrane preparations in the presence of enhancers such as lucigenin, luminol, or L012. However, the ability of these particular assays to specifically detect Nox...

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PMID: 25906178
DOI: 10.1089/ars.2015.6314

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