The +49A>G CTLA-4 polymorphism is associated with rheumatoid arthritis in Mexican population.

doi:10.1016/j.cca.2010.02.001

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Article

The +49A>G CTLA-4 polymorphism is associated with rheumatoid arthritis in Mexican population.

Clinica chimica acta; international journal of clinical chemistry - 2 May 2010

Muñoz-Valle José F, Valle Yeminia, Padilla-Gutiérrez Jorge R, Parra-Rojas Isela, Rangel-Villalobos Hector, Vázquez del Mercado Mónica, Ledezma-Lozano Iris Y, Villafan-Bernal José R, Armendáriz-Borunda Juan, Pereira-Suárez Ana Laura

Abstract excerpt

BACKGROUND: The Cytotoxic T lymphocyte antigen (CTLA-4) is one of the major susceptibility genes associated with autoimmune diseases. Susceptibility to rheumatoid arthritis (RA) is determined by both environmental and genetic factors. The genetic contribution approaches 50-60%. The association between RA with the +49A>G CTLA-4 polymorphism in the Mexican population was investigated. METHODS: The polymerase chain...

Topics

Adult
Antigens, CD
Arthritis, Rheumatoid
Blood Sedimentation
C-Reactive Protein
CTLA-4 Antigen
Female
Gene Frequency
Genotype
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homozygote

Humans

Male

Mexico

Middle Aged

Polymorphism, Single Nucleotide

Rheumatoid Factor

Source

Open in PubMed

Identifiers

PMID: 20138855
DOI: 10.1016/j.cca.2010.02.001

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