Article

A N-propionylsulfonamide prodrug of K-5a2 provided improved aqueous solubility and hERG inhibition

2020-05-13

Abstract excerpt

<title>Abstract</title> <p>Background Having the potential disadvantages and safety risk of the use of anti-HIV-1 drug candidate <bold>K-5a2</bold> in the longterm treatment of HIV patients in mind, we set out with the goal of finding a second-generation backup compound of <bold>K-5a2</bold> with the appropriate anti-HIV potency, significantly reduced hERG activity, decreased induction of the CYP enzyme, and impr...

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Literature Corpus work: d89c87f3-165e-5978-853e-8b2531c13f23
DOI: 10.21203/rs.3.rs-20505/v1

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