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Article

Cytomegalovirus protease targeted prodrug development.

Molecular pharmaceutics - 1 Apr 2013

Sabit Hairat, Dahan Arik, Sun Jing, Provoda Chester J, Lee Kyung-Dall, Hilfinger John H, Amidon Gordon L

Abstract excerpt

Human cytomegalovirus (HCMV) is a prevalent virus that infects up to 90% of the population. The goal of this research is to determine if small molecular prodrug substrates can be developed for a specific HCMV encoded protease and thus achieve site-specific activation. HCMV encodes a 256 amino acid serine protease that is responsible for capsid assembly, an essential process for herpes virus production. The...

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Identifiers

PMID: 23485093
DOI: 10.1021/mp3007067
PMCID: PMC3616455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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