Article
Synthesis and biological activity of 2-fluoro adenine and 6-methyl purine nucleoside analogs as prodrugs for suicide gene therapy of cancer.
Nucleosides, nucleotides & nucleic acids - 1 Jan 2005
Silamkoti A V, Allan P W, Hassan A E A, Fowler A T, Sorscher E J, Parker W B, Secrist J A
Abstract excerpt
A novel series of 6-methylpurine nucleoside derivatives with substitutions at 5-position have been synthesised These compounds bear a 5'-heterocycle such as triazole or a imidazole with a two carbon chain, and an ether, thio ether or amine. To extend the SAR study of 2-fluoroadenine and 6-methyl purine nucleosides, their corresponding alpha-linker nucleosides with L-xylose and L-lyxose were also synthesized. All...
Topics
- Adenine
- Antineoplastic Agents
- Carbon
- Escherichia coli
- Genetic Therapy
- Humans
- Models, Chemical
- Mutation
- Neoplasms
- Nucleosides
- Prodrugs