2, 4, 6, 8, who's afraid to phosphorylate?

Abstract excerpt

It is important to consider factors such as pharmacological mechanisms when planning long-range drug therapies. Nucleoside analogs are prodrugs that must be converted into an active form by cellular enzymes in the body; this process is called phosphorylation. Controversy exists about whether the rate of phosphorylation decreases after long-term exposure to a drug. Data is presented from the 1998 Retrovirus...

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