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Article

The mutationally activated Met receptor mediates motility and metastasis

24 Nov 1998

Abstract excerpt

Mutations in Met have been identified in human papillary renal carcinomas. We have shown previously that these mutations deregulate the enzymatic activity of Met and that NIH 3T3 cells expressing mutationally activated Met are transformed in vitro and are tumorigenic in vivo. In the present investigation, we find that mutant Met induces the motility of Madin-Darby canine kidney cells in vitro and experimental...

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Identifiers

PMID: 9826715
DOI: 10.1073/pnas.95.24.14417

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