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Article

Role of electrostatics and salt bridges in stabilizing the compound I radical in ascorbate peroxidase.

Biochemistry - 1 Nov 2005

Barrows Tiffany P, Poulos Thomas L

Abstract excerpt

Cytochrome c (CcP) and ascorbate peroxidase (APX) are heme peroxidases which have very similar active site structures yet differ substantially in the properties of compound I, the intermediate formed upon reaction with peroxides. Although both peroxidases have a tryptophan in the proximal heme pocket, Trp191 in CcP and Trp179 in APX, only Trp191 in CcP forms a stable cation radical while APX forms the more...

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PMID: 16245922
DOI: 10.1021/bi0507128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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