Article
Solution NMR structures of IgG binding domains with artificially evolved high levels of sequence identity but different folds.
Biochemistry - 1 Nov 2005
He Yanan, Yeh Deok Cheon, Alexander Patrick, Bryan Philip N, Orban John
Abstract excerpt
We describe here the solution NMR structures of two IgG binding domains with highly homologous sequences but different three-dimensional structures. The proteins, G311 and A219, are derived from the IgG binding domains of their wild-type counterparts, protein G and protein A, respectively. Through a series of site-directed mutations and phage display selections, the sequences of G311 and A219 were designed to...
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