Article
A minimal sequence code for switching protein structure and function.
Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 2009
Alexander Patrick A, He Yanan, Chen Yihong, Orban John, Bryan Philip N
Abstract excerpt
We present here a structural and mechanistic description of how a protein changes its fold and function, mutation by mutation. Our approach was to create 2 proteins that (i) are stably folded into 2 different folds, (ii) have 2 different functions, and (iii) are very similar in sequence. In this simplified sequence space we explore the mutational path from one fold to another. We show that an IgG-binding,...
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