Article
Noradrenergic blockade prevents attacks in a model of episodic dysfunction caused by a channelopathy.
Neurobiology of disease - 1 Nov 2005
Fureman Brandy E, Hess Ellen J
Abstract excerpt
Episodic neurological dysfunction often results from ion channel gene mutations. Despite knowledge of the mutations, the factors that precipitate attacks in channelopathies are not clear. In humans, mutations of the calcium channel gene CACNA1A are associated with attacks of neurological dysfunction in familial hemiplegic migraine and episodic ataxia type-2. In tottering mice, a mutation in the same gene causes...
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