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Article

KCa channels as therapeutic targets in episodic ataxia type-2.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 May 2010

Alviña Karina, Khodakhah Kamran

Abstract excerpt

Episodic ataxia type-2 (EA2) is an inherited movement disorder caused by mutations in the gene encoding the Ca(v)2.1alpha1 subunit of the P/Q-type voltage-gated calcium channel that result in an overall reduction in the P/Q-type calcium current. A consequence of these mutations is loss of precision of pacemaking in cerebellar Purkinje cells. This diminished precision reduces the information encoded by Purkinje...

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Identifiers

PMID: 20505091
DOI: 10.1523/JNEUROSCI.6341-09.2010
PMCID: PMC2909841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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