<i>In vivo</i>, <i>fliC</i> expression by <i>Salmonella enterica</i> serovar Typhimurium is heterogeneous, regulated by ClpX, and anatomically restricted

Abstract excerpt

FliC is a natural antigen recognized by the innate and adaptive immune systems during Salmonella infection in mice and humans; however, the regulatory mechanisms governing its expression in vivo are incompletely understood. Here, we use flow cytometry to quantify fliC gene expression in single bacteria. In vitro, fliC transcription was not uniformly positive; a viable fliC-negative subpopulation was also...

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