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Article

Tus-mediated arrest of DNA replication in Escherichia coli is modulated by DNA supercoiling.

Molecular microbiology - 1 Nov 2005

Valjavec-Gratian Majda, Henderson Thomas A, Hill Thomas M

Abstract excerpt

In the absence of RecA, expression of the Tus protein of Escherichia coli is lethal when ectopic Ter sites are inserted into the chromosome in an orientation that blocks completion of chromosome replication. Using this observation as a basis for genetic selection, an extragenic suppressor of Tus-mediated arrest of DNA replication was isolated with diminished ability of Tus to halt DNA replication. Resistance to...

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Identifiers

PMID: 16238625
DOI: 10.1111/j.1365-2958.2005.04860.x

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Tus-mediated arrest of DNA replication in Escherichia coli is modulated by DNA supercoiling.PMID 16238625Read ↗

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