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Article

Replication termination mechanism as revealed by Tus-mediated polar arrest of a sliding helicase.

Proceedings of the National Academy of Sciences of the United States of America - 2 Sept 2008

Bastia Deepak, Zzaman Shamsu, Krings Gregor, Saxena Mukesh, Peng Xiaohua, Greenberg Marc M

Abstract excerpt

The replication terminator protein Tus of Escherichia coli promotes polar fork arrest at sequence-specific replication termini (Ter) by antagonizing DNA unwinding by the replicative helicase DnaB. Here, we report that Tus is also a polar antitranslocase. We have used this activity as a tool to uncouple helicase arrest at a Tus-Ter complex from DNA unwinding and have shown that helicase arrest occurred without the...

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Identifiers

PMID: 18708526
DOI: 10.1073/pnas.0805898105
PMCID: PMC2529109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Replication termination mechanism as revealed by Tus-mediated polar arrest of a sliding helicase.PMID 18708526Read ↗

Differential Tus-Ter binding and lock formation: implications for DNA replication termination in Escherichia coli.Semantic proximity Read ↗

Strand separation establishes a sustained lock at the Tus-Ter replication fork barrier.Semantic proximity Read ↗

Sequence-specific interactions in the Tus-Ter complex and the effect of base pair substitutions on arrest of DNA replication in Escherichia coli.Semantic proximity Read ↗

Tus-mediated arrest of DNA replication in Escherichia coli is modulated by DNA supercoiling.Semantic proximity Read ↗

Isolation and characterization of mutants of Tus, the replication arrest protein of Escherichia coli.Semantic proximity Read ↗

Mutational bias suggests that replication termination occurs near the dif site, not at Ter sites.Semantic proximity Read ↗

A molecular mousetrap determines polarity of termination of DNA replication in E. coli.Semantic proximity Read ↗

In vivo effect of the tus mutation on cell division in an Escherichia coli strain where chromosome replication is under the control of plasmid R1.Semantic proximity Read ↗

Replication arrests during a single round of replication of the Escherichia coli chromosome in the absence of DnaC activity.Semantic proximity Read ↗

A single domain of the replication termination protein of Bacillus subtilis is involved in arresting both DnaB helicase and RNA polymerase.Semantic proximity Read ↗

A complex mechanism determines polarity of DNA replication fork arrest by the replication terminator complex of Bacillus subtilis.Semantic proximity Read ↗

In vivo and in vitro evidence for an anti-Rho activity induced by the phage P4 polarity suppressor protein Psu.Semantic proximity Read ↗

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