Article
Association between the casein kinase 1 epsilon gene region and subjective response to D-amphetamine.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2006
Veenstra-VanderWeele Jeremy, Qaadir Asfia, Palmer Abraham A, Cook Edwin H, de Wit Harriet
Abstract excerpt
Animal models suggest that the casein kinase 1 epsilon gene (Csnk1e) contributes to variability in stimulant response. Csnk1e is a key component in the Darpp-32 (Dopamine-And-cAMP-Regulated-Phosphoprotein-32 kDa) second messenger pathway and has been implicated in previous pharmacological and pharmacogenetic studies in mice. Mice bred for methamphetamine sensitivity showed linkage to the region of chromosome 15...
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