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Article

Association between a casein kinase 1 ε gene polymorphism and schizophrenia in a Chinese Han population.

Journal of molecular neuroscience : MN - 1 Jul 2012

Huang Yinglin, Li Jingying, Wu Lijuan, Jin Qiu, Zhao Xiaofeng, Li Jun, Zhu Gang

Abstract excerpt

The casein kinase 1 (Csnk1) family of serine/threonine kinases regulates dopamine receptor (DR) signaling by phosphorylating the 32-kDa dopamine- and cAMP-regulated phosphoprotein DARPP-32, leading to inhibition of protein phosphatase 1 and a shift in the phosphorylation state of many downstream proteins. By modulating DR-activated phosphorylation cascades, Csnk1 plays a central role in neuropsychiatric disorders...

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PMID: 22367616
DOI: 10.1007/s12031-012-9729-1

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