Article
Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity.
Nature immunology - 1 Dec 2004
Ansel K Mark, Greenwald Rebecca J, Agarwal Suneet, Bassing Craig H, Monticelli Silvia, Interlandi Jeneen, Djuretic Ivana M, Lee Dong U, Sharpe Arlene H, Alt Frederick W, Rao Anjana
Abstract excerpt
Helper T cell differentiation involves silencing as well as activation of gene expression. We have identified a conserved silencer of the gene encoding interleukin 4 (Il4) marked by DNase I hypersensitivity (HS IV) and permissive chromatin structure in all helper T cells. Deletion of HS IV increased Il4 and Il13 transcription by naive T cells and led to T helper type 2 skewing in vitro. HS IV controlled Il4...
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