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Epigenetic Control of IFN-γ Host Responses During Infection With Toxoplasma gondii

25 Sept 2020

Abstract excerpt

Host defense against the human pathogen Toxoplasma gondii depends on secretion of interferon (IFN)-γ and subsequent activation of monocytic cells to combat intracellular parasites. Previous studies have shown that T. gondii evades IFN-γ-mediated immunity by secreting the effector TgIST into the host cell where it binds to STAT1, strengthens its DNA binding activity and recruits the Mi-2/NuRD complex to...

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PMID: 33072127
DOI: 10.3389/fimmu.2020.581241

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