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Article

Fine mapping of the psoriasis susceptibility locus PSORS1 supports HLA-C as the susceptibility gene in the Han Chinese population.

PLoS genetics - 21 Mar 2008

Fan Xing, Yang Sen, Huang Wei, Wang Zhi-Min, Sun Liang-Dan, Liang Yan-Hua, Gao Min, Ren Yue-Qing, Zhang Kai-Yue, Du Wen-Hui, Shen Yu-Jun, Liu Jian-Jun, Zhang Xue-Jun

Abstract excerpt

PSORS1 (psoriasis susceptibility gene 1) is a major susceptibility locus for psoriasis. Several fine-mapping studies have highlighted a 300-kb candidate region of PSORS1 where multiple biologically plausible candidate genes were suggested. The most recent study has indicated HLA-Cw6 as the primary PSORS1 risk allele within the candidate region in a Caucasian population. In this study, a family-based association...

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Identifiers

PMID: 18369457
DOI: 10.1371/journal.pgen.1000038
PMCID: PMC2265413

Genes

CDSN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fine mapping of the psoriasis susceptibility locus PSORS1 supports HLA-C as the susceptibility gene in the Han Chinese population.PMID 18369457Read ↗

Mapping of the major psoriasis-susceptibility locus (PSORS1) in a 70-Kb interval around the corneodesmosin gene (CDSN).Semantic proximity Read ↗

Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.Semantic proximity Read ↗

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An in-depth characterization of the major psoriasis susceptibility locus identifies candidate susceptibility alleles within an HLA-C enhancer element.Semantic proximity Read ↗

A study of PSORS1C1 gene polymorphisms in Chinese patients with psoriasis.Semantic proximity Read ↗

Family-based analysis using a dense single-nucleotide polymorphism-based map defines genetic variation at PSORS1, the major psoriasis-susceptibility locus.Semantic proximity Read ↗

Fine mapping of the PSORS4 psoriasis susceptibility region on chromosome 1q21.Semantic proximity Read ↗

Psoriasis vulgaris in Chinese individuals is associated with PSORS1C3 and CDSN genes.Semantic proximity Read ↗

Localization of psoriasis-susceptibility locus PSORS1 to a 60-kb interval telomeric to HLA-C.Semantic proximity Read ↗

HLA-Cw*0602 associates more strongly to psoriasis in the Swedish population than variants of the novel 6p21.3 gene PSORS1C3.Semantic proximity Read ↗

Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR.Semantic proximity Read ↗

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