Article
Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus.
Human molecular genetics - 1 Mar 2002
Asumalahti Kati, Veal Colin, Laitinen Tarja, Suomela Sari, Allen Michael, Elomaa Outi, Moser Michael, de Cid Rafael, Ripatti Samuli, Vorechovsky Igor, Marcusson Jan A, Nakagawa Hidemi, Lazaro Conxi, Estivill Xavier, Capon Francesca, Novelli Giuseppe, Saarialho-Kere Ulpu, Barker Jonathan, Trembath Richard, Kere Juha
Abstract excerpt
PSORS1, near HLA-C, is the major genetic determinant of psoriasis. We present genetic and structural evidence suggesting a major role for the HCR gene at the PSORS1 locus. Genotyping of 419 families from six populations revealed that coding single-nucleotide polymorphisms of HCR formed a conserved allele HCR*WWCC that associated highly significantly with psoriasis and with the HLA-Cw6 allele in all populations....
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