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Article

Immunohistochemical expression of DNA repair proteins in familial breast cancer differentiate BRCA2-associated tumors.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Oct 2005

Honrado Emiliano, Osorio Ana, Palacios José, Milne Roger L, Sánchez Lydia, Díez Orland, Cazorla Alicia, Syrjakoski Kirsi, Huntsman David, Heikkilä Päivi, Lerma Enrique, Kallioniemi Anne, Rivas Carmen, Foulkes William D, Nevanlinna Heli, Benítez Javier

Abstract excerpt

PURPOSE: Morphologic and immunohistochemical studies of familial breast cancers have identified specific characteristics associated with BRCA1 mutation-associated tumors when compared with BRCA2 and non-BRCA1/2 tumors, but have not identified differences between BRCA2 and non-BRCA1/2 tumors. Because BRCA1 and BRCA2 genes participate in the DNA repair pathway, we have performed an immunohistochemical study with...

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Source

Identifiers

PMID: 16234517
DOI: 10.1200/JCO.2005.01.3698

Genes

BRCA1
BRCA2
CHEK2
RAD51
ATM
RAD50
XRCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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