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Article

Pancreaticobiliary cancers with deficient methylenetetrahydrofolate reductase genotypes.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Aug 2005

Matsubayashi Hiroyuki, Skinner Halcyon G, Iacobuzio-Donahue Christine, Abe Tadayoshi, Sato Norihiro, Riall Taylor Sohn, Yeo Charles J, Kern Scott E, Goggins Michael

Abstract excerpt

BACKGROUND & AIMS: Methyl group deficiency might promote carcinogenesis by inducing DNA breaks and DNA hypomethylation. We hypothesized that deficient methylenetetrahydrofolate reductase (MTHFR) genotypes could promote pancreatic cancer development. METHODS: First, we performed a case-control study of germline MTHFR polymorphisms (C677T, A1298C) in 303 patients with pancreatic cancer and 305 matched control...

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Identifiers

PMID: 16234003
DOI: 10.1016/s1542-3565(05)00359-9

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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