Article
Optimization of diagnostic strategy for non-invasive cell-free foetal RHD determination from maternal plasma.
Vox sanguinis - 1 Oct 2021
Pazourkova Eva, Zednikova Iveta, Korabecna Marie, Kralova Jana, Pisacka Martin, Novotna Michaela, Calda Pavel, Horinek Ales
Abstract excerpt
BACKGROUND AND OBJECTIVES: The aim of the study was to optimize routine non-invasive prenatal detection of fetal RHD gene from plasma of RhD-negative pregnant women (the median of gestational age was 25 weeks, range 10-38) to detect RhD materno-fetal incompatibility and to avoid the redundant immunoprophylaxis. MATERIALS AND METHODS: Initially only one exon of RHD gene (exon 10) was investigated in 281 plasma...
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