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Article

Association between large-scale genomic homozygosity without chromosomal loss and nonseminomatous germ cell tumor development.

Cancer research - 15 Oct 2005

Lu Yong-Jie, Yang Jinshu, Noel Elodie, Skoulakis Spyros, Chaplin Tracy, Raghavan Manoj, Purkis Trisha, McIntyre Alan, Kudahetti Sakunthala C, Naase Mahmoud, Berney Dan, Shipley Janet, Oliver R Timothy D, Young Bryan D

Abstract excerpt

The genotype of a tumor determines its biology and clinical behavior. The genetic alterations associated with the unique embryonal morphology of nonseminomatous subtypes of testicular germ cell tumors remain to be established. Using single nucleotide polymorphism microarray analysis, we found in all of the 15 nonseminomas analyzed, large-scale chromosomal homozygosities, most of which were not associated with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to In Situ Hybridization, Fluorescence

Share to Neoplasms, Germ Cell and Embryonal

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Share to Polymorphism, Single Nucleotide

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PMID: 16230368
DOI: 10.1158/0008-5472.CAN-05-1697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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