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Article

Extracellular cleavage of E-cadherin by leukocyte elastase during acute experimental pancreatitis in rats.

Gastroenterology - 1 Oct 2005

Mayerle Julia, Schnekenburger Jürgen, Krüger Burkhard, Kellermann Josef, Ruthenbürger Manuel, Weiss F Ulrich, Nalli Angel, Domschke Wolfram, Lerch Markus M

Abstract excerpt

BACKGROUND & AIMS: Cadherins play an important role in cell-cell contact formation at adherens junctions. During the course of acute pancreatitis, adherens junctions are known to dissociate-a requirement for the interstitial accumulation of fluid and inflammatory cells-but the underlying mechanism is unknown. METHODS: Acute pancreatitis was induced in rats by supramaximal cerulein infusion. The pancreas and lungs...

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Source

Identifiers

PMID: 16230078
DOI: 10.1053/j.gastro.2005.08.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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