Article

Neutrophil Elastase Activates Macrophage MMPs, Promotes Cell Adhesion and Cytokine Production Via Integrin-Src Kinases Pathway

2018-12-02

Abstract excerpt

<h4>ABSTRACT</h4> There are a number of diseases characterized by the presence of neutrophil elastase (NE) activity in tissues including cystic fibrosis and alpha-1-antitrypsin deficiency induced lung destruction. It is generally accepted that NE actively contributes to this pathological process, but the precise mechanisms has yet to be determined. We hypothesized that NE activates the macrophages (M□) pro-inflam...

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Literature Corpus work: d4cd2e92-58b8-5ce6-b999-e8ffbbea521f
DOI: 10.1101/474395

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