Article
Tumor promotion by caspase-resistant retinoblastoma protein.
Proceedings of the National Academy of Sciences of the United States of America - 25 Oct 2005
Borges Helena L, Bird Jeff, Wasson Katherine, Cardiff Robert D, Varki Nissi, Eckmann Lars, Wang Jean Y J
Abstract excerpt
The retinoblastoma (RB) protein regulates cell proliferation and cell death. RB is cleaved by caspase during apoptosis. A mutation of the caspase-cleavage site in the RB C terminus has been made in the mouse Rb-1 locus; the resulting Rb-MI mice are resistant to endotoxin-induced apoptosis in the intestine. The Rb-MI mice do not exhibit increased tumor incidence, because the MI mutation does not disrupt the Rb...
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