Article
Restoration of transforming growth factor-beta signaling enhances radiosensitivity by altering the Bcl-2/Bax ratio in the p53 mutant pancreatic cancer cell line MIA PaCa-2.
The Journal of biological chemistry - 18 Jan 2002
Ahmed Mansoor M, Alcock Rachael A, Chendil Damodaran, Dey Swatee, Das Anindita, Venkatasubbarao Kolaparthi, Mohiuddin Mohammed, Sun LuZhe, Strodel William E, Freeman James W
Abstract excerpt
In this study, we investigated whether lack of transforming growth factor beta (TGF-beta) type II receptor (RII) expression and loss of TGF-beta signaling played a role in radiation resistance of pancreatic cancer cells MIA PaCa-2 that possess a mutated p53 gene. Transfection of this cell line with a RII cDNA led to a stimulation of the transcriptional activity of p3TP-Lux, a TGF-beta-responsive reporter...
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