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Article

p53 Mediates TNF-Induced Epithelial Cell Apoptosis in IBD

3 Aug 2012

Abstract excerpt

Chronic ulcerative colitis (CUC) is characterized by increased intestinal epithelial cell (IEC) apoptosis associated with elevated tumor necrosis factor (TNF), inducible nitric oxide synthase (iNOS), and p53. We previously showed that p53 is increased in crypt IECs in human colitis and is needed for IEC apoptosis in chronic dextran sulfate sodium-colitis. Herein, we examined the roles of TNF and iNOS in...

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PMID: 22863952
DOI: 10.1016/j.ajpath.2012.06.016

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