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Article

Alpha interferon inhibits translation mediated by the internal ribosome entry site of six different hepatitis C virus genotypes.

The Journal of general virology - 1 Nov 2005

Hazari Sidhartha, Patil Asha, Joshi Virendra, Sullivan Deborah E, Fermin Cesar D, Garry Robert F, Elliott Richard M, Dash Srikanta

Abstract excerpt

Certain genotypes of hepatitis C virus (HCV) respond less often than others to treatment with interferon (IFN). The mechanisms for this differential response are not known. In this report antiviral effects of IFN-alpha2b on translation were examined in a hepatic cell line using chimeric clones of internal ribosome entry site (IRES) sequences from six different HCV genotypes and the green fluorescence protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16227227
DOI: 10.1099/vir.0.81132-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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