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Article

DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity.

The Journal of biological chemistry - 30 Dec 2005

Zhou Wenbo, Freed Curt R

Abstract excerpt

DJ-1 is the third gene that has been linked to Parkinson disease. Mutations in the DJ-1 gene cause early onset PD with autosomal recessive inheritance. To clarify the mechanism of DJ-1 protection, we have overexpressed the gene in cultured dopaminergic cells that were then subjected to chemical s...

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Identifiers

PMID: 16227205
DOI: 10.1074/jbc.M507124200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16227205-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity.PMID 16227205Read ↗

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Regulation of DJ-1 by Glutaredoxin 1 in Vivo: Implications for Parkinson’s DiseaseSemantic proximity Read ↗

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Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection.Semantic proximity Read ↗

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Human DJ-1 and its homologs are novel glyoxalasesSemantic proximity Read ↗

Lessons from Drosophila models of DJ-1 deficiency.Semantic proximity Read ↗

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