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Article

DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity.

The Journal of biological chemistry - 30 Dec 2005

Zhou Wenbo, Freed Curt R

Abstract excerpt

DJ-1 is the third gene that has been linked to Parkinson disease. Mutations in the DJ-1 gene cause early onset PD with autosomal recessive inheritance. To clarify the mechanism of DJ-1 protection, we have overexpressed the gene in cultured dopaminergic cells that were then subjected to chemical stress. In the rat dopaminergic cell line, N27, and in primary dopamine neurons, overexpression of wild type DJ-1...

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Identifiers

PMID: 16227205
DOI: 10.1074/jbc.M507124200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity.PMID 16227205Read ↗

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Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection.Semantic proximity Read ↗

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Human DJ-1 and its homologs are novel glyoxalasesSemantic proximity Read ↗

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