Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation.

PLoS biology - 1 Nov 2004

Shendelman Shoshana, Jonason Alan, Martinat Cecile, Leete Thomas, Abeliovich Asa

Abstract excerpt

Parkinson's disease (PD) pathology is characterized by the degeneration of midbrain dopamine neurons (DNs) ultimately leading to a progressive movement disorder in patients. The etiology of DN loss in sporadic PD is unknown, although it is hypothesized that aberrant protein aggregation and cellular oxidative stress may promote DN degeneration. Homozygous mutations in DJ-1 were recently described in two families...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Antioxidants
Share to Dopamine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oncogene Proteins

Share to Oxygen

Share to Protein Deglycase DJ-1

Share to Spectrophotometry

Share to Synucleins

Source

Open in PubMed Open full text

Identifiers

PMID: 15502874
DOI: 10.1371/journal.pbio.0020362
PMCID: PMC521177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation.PMID 15502874Read ↗

Pathogenesis of DJ-1/PARK7-Mediated Parkinson’s DiseaseSemantic proximity Read ↗

DJ-1 modulates aggregation and pathogenesis in models of Huntington's disease.Semantic proximity Read ↗

DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease.Semantic proximity Read ↗

Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress.Semantic proximity Read ↗

Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease.Semantic proximity Read ↗

DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity.Semantic proximity Read ↗

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism.Semantic proximity Read ↗

Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress.Semantic proximity Read ↗

Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease.Semantic proximity Read ↗

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress.Semantic proximity Read ↗

Structural Biology of the DJ-1 Superfamily.Semantic proximity Read ↗

Lessons from Drosophila models of DJ-1 deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.