Article
YND1 interacts with CDC55 and is a novel mediator of E4orf4-induced toxicity.
The Journal of biological chemistry - 16 Dec 2005
Maoz Tsofnat, Koren Roni, Ben-Ari Inbal, Kleinberger Tamar
Abstract excerpt
Adenovirus E4orf4 (early region 4 open reading frame 4) protein induces protein phosphatase 2A-dependent non-classical apoptosis in mammalian cells and irreversible growth arrest in Saccharomyces cerevisiae. Oncogenic transformation sensitizes cells to E4orf4-induced cell death. To uncover additional components of the E4orf4 network required for induction of its unique mode of apoptosis, we used yeast genetics to...
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