Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Adenovirus E4orf4 Protein Induces G <sub>2</sub> /M Arrest and Cell Death by Blocking Protein Phosphatase 2A Activity Regulated by the B55 Subunit

18 Jun 2009

Abstract excerpt

Human adenovirus E4orf4 protein is toxic in human tumor cells. Its interaction with the B alpha subunit of protein phosphatase 2A (PP2A) is critical for cell killing; however, the effect of E4orf4 binding is not known. B alpha is one of several mammalian B-type regulatory subunits that form PP2A holoenzymes with A and C subunits. Here we show that E4orf4 protein interacts uniquely with B55 family subunits and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Viral Infectious Diseases and Gene Expression in Insects
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19535438
DOI: 10.1128/jvi.00711-09

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Adenovirus E4orf4 Protein Induces G <sub>2</sub> /M Arrest and Cell Death by Blocking Protein Phosphatase 2A Activity Regulated by the B55 SubunitPMID 19535438Read ↗

Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2ASemantic proximity Read ↗

Adenovirus E4orf4 protein interacts with both Bα and B′ subunits of protein phosphatase 2A, but E4orf4-induced apoptosis is mediated only by the interaction with BαSemantic proximity Read ↗

Toxicity of human adenovirus E4orf4 protein in Saccharomyces cerevisiae results from interactions with the Cdc55 regulatory B subunit of PP2ASemantic proximity Read ↗

Adenovirus E4orf4 protein downregulates MYC expression through interaction with the PP2A-B55 subunit.Semantic proximity Read ↗

The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response.Semantic proximity Read ↗

E4orf4 induces PP2A- and Src-dependent cell death in Drosophila melanogaster and at the same time inhibits classic apoptosis pathways.Semantic proximity Read ↗

Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity.Semantic proximity Read ↗

Infection with E1B-mutant adenovirus stabilizes p53 but blocks p53 acetylation and activity through E1A.Semantic proximity Read ↗

Cyclin-dependent kinase 4 may be expressed as multiple proteins and have functions that are independent of binding to CCND and RB and occur at the S and G 2/M phases of the cell cycle.Semantic proximity Read ↗

The role of adenovirus E4orf4 protein in viral replication and cell killingSemantic proximity Read ↗

YND1 interacts with CDC55 and is a novel mediator of E4orf4-induced toxicity.Semantic proximity Read ↗

Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.