Article
Epidermal growth factor receptor expression status in lung cancer correlates with its mutation.
Human pathology - 1 Oct 2005
Suzuki Makoto, Shigematsu Hisayuki, Hiroshima Kenzo, Iizasa Toshihiko, Nakatani Yukio, Minna John D, Gazdar Adi F, Fujisawa Takehiko
Abstract excerpt
The molecular mechanisms for frequent epidermal growth factor receptor (EGFR, a tyrosine kinase [TK]) and HER2 (the preferred coreceptor of EGFR) overexpression in lung cancer are poorly understood. Recent studies have shown the mutations of the TK domain in EGFR and HER2 to be present in lung cancer. The purpose of this study was to investigate the relationship between mutation status and expression of EGFR and...
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