Article
Epidermal growth factor receptor abnormalities in lung cancer. Pathogenetic and clinical implications.
Annals of diagnostic pathology - 1 Oct 2006
Prudkin Ludmila, Wistuba Ignacio I
Abstract excerpt
The discovery that mutation of the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) gene occurs in a subset of lung cancers and predicts for sensitivity to tyrosine kinase inhibitors has generated enormous interest and immediately led to intense basic, translational, and clinical research in many laboratories around the globe. All these findings have led to the identification of a subset of...
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