[Epidermal growth factor receptor gene mutations, amplification and clinicopathologic correlation in patients with lung cancer].

Abstract excerpt

OBJECTIVE: To investigate the clinicopathological features of patients with lung cancers associated with epidermal growth factor receptor (EGFR) gene amplification and/or mutations. METHODS: Mutations and amplification status of EGFR gene were detected by PCR-DNA sequencing and FISH, respectively, followed by subsequent clinicopathological correlative studies. RESULTS: Among 454 patients, the overall mutation...

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