Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Smad proteins regulate transcriptional induction of the SM22alpha gene by TGF-beta.

Nucleic acids research - 15 Feb 2003

Chen Shiyou, Kulik Magdalena, Lechleider Robert J

Abstract excerpt

Smad proteins transduce signals from transforming growth factor-beta (TGF-beta) receptors and regulate transcription of target genes. TGF-beta is implicated in the regulation of the smooth muscle cell specific gene SM22alpha, but little is known about how Smads are involved in SM22alpha gene transcription. In this report, we demonstrate that TGF-beta activation of the SM22alpha promoter is Smad dependent in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Electrophoretic Mobility Shift Assay
Share to Luciferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Smad Proteins

Share to Smad1 Protein

Share to Smad3 Protein

Share to Smad4 Protein

Share to Transcription Factor AP-1

Source

Open in PubMed Open full text

Identifiers

PMID: 12582250
DOI: 10.1093/nar/gkg224
PMCID: PMC150242

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Smad proteins regulate transcriptional induction of the SM22alpha gene by TGF-beta.PMID 12582250Read ↗

Interaction of Smad3 and SRF-associated complex mediates TGF-beta1 signals to regulate SM22 transcription during myofibroblast differentiation.Semantic proximity Read ↗

Myocardin Enhances Smad3-Mediated Transforming Growth Factor-β <sub>1</sub> Signaling in a CArG Box-Independent MannerSemantic proximity Read ↗

Cooperation of myocardin and smad2 in inducing differentiation of mesenchymal stem cells into smooth muscle cellsSemantic proximity Read ↗

Transforming growth factor-beta1 up-regulation of human alpha(1)(I) collagen is mediated by Sp1 and Smad2 transacting factors.Semantic proximity Read ↗

Smad2 and PEA3 cooperatively regulate transcription of response gene to complement 32 in TGF-β-induced smooth muscle cell differentiation of neural crest cells.Semantic proximity Read ↗

Vascular smooth muscle alpha-actin gene transcription during myofibroblast differentiation requires Sp1/3 protein binding proximal to the MCAT enhancer.Semantic proximity Read ↗

Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression.Semantic proximity Read ↗

Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF‐βSemantic proximity Read ↗

Smads are the central component in transforming growth factor-beta signaling.Semantic proximity Read ↗

Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-beta/Smad4 signalling pathway is potentiated by Sp1Semantic proximity Read ↗

Efficient TGF-β Induction of the Smad7 Gene Requires Cooperation between AP-1, Sp1, and Smad Proteins on the Mouse Smad7 PromoterSemantic proximity Read ↗

Participation of Smad2, Smad3, and Smad4 in Transforming Growth Factor β (TGF-β)-induced Activation of Smad7Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.