Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dominant negative mutation of the TGF-beta receptor blocks hypoxia-induced pulmonary vascular remodeling.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Feb 2006

Chen Yiu-Fai, Feng Ji-An, Li Peng, Xing Dongqi, Zhang Yun, Serra Rosa, Ambalavanan Namasivayam, Majid-Hassan Erum, Oparil Suzanne

Abstract excerpt

The present study utilized a novel transgenic mouse model that expresses an inducible dominant negative mutation of the transforming growth factor (TGF)-beta type II receptor (DnTGFbetaRII mouse) to test the hypothesis that TGF-beta signaling plays an important role in the pathogenesis of chronic hypoxia-induced increases in pulmonary arterial pressure and vascular and alveolar remodeling. Nine- to 10-wk-old male...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fibronectins
Share to Hypertension, Pulmonary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia

Share to Muscle, Smooth, Vascular

Share to Pulmonary Alveoli

Share to Pulmonary Artery

Share to Receptor, Transforming Growth Factor-beta Type II

Share to Receptors, Transforming Growth Factor beta

Source

Identifiers

PMID: 16223981
DOI: 10.1152/japplphysiol.00595.2005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dominant negative mutation of the TGF-beta receptor blocks hypoxia-induced pulmonary vascular remodeling.PMID 16223981Read ↗

Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle.Semantic proximity Read ↗

Transforming growth factor beta/bone morphogenic protein signaling in pulmonary arterial hypertension: remodeling revisited.Semantic proximity Read ↗

Hypoxia‐induced pulmonary hypertension upregulates eNOS and TGF‐β contributing to sex‐linked differences in BMPR2+/R899X mutant miceSemantic proximity Read ↗

Targeted gene delivery of <i>BMPR2</i> attenuates pulmonary hypertensionSemantic proximity Read ↗

Myofiber-specific inhibition of TGFβ signaling protects skeletal muscle from injury and dystrophic disease in mice.Semantic proximity Read ↗

Hypoxia-Inducible Factor 1α Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELMα)-Induced Pulmonary Hypertension.Semantic proximity Read ↗

Overexpression of a Kinase-deficient Transforming Growth Factor-β Type II Receptor in Mouse Mammary Stroma Results in Increased Epithelial BranchingSemantic proximity Read ↗

Mesodermal Deletion of Transforming Growth Factor-β Receptor II Disrupts Lung Epithelial MorphogenesisSemantic proximity Read ↗

Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung.Semantic proximity Read ↗

An Essential Role for Resident Fibroblasts in Experimental Lung Fibrosis Is Defined by Lineage-Specific Deletion of High-Affinity Type II Transforming Growth Factor β ReceptorSemantic proximity Read ↗

BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia.Semantic proximity Read ↗

Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.