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Article

Targeted gene delivery of <i>BMPR2</i> attenuates pulmonary hypertension

7 Jul 2011

Abstract excerpt

Pulmonary arterial hypertension (PAH) remains a fatal disease despite modern pharmacotherapy. Mutations in the gene for bone morphogenetic protein receptor type II (BMPR2) lead to reduced BMPR2 expression, which is causally linked to PAH. BMPR2 is predominantly expressed on pulmonary endothelium and has complex interactions with transforming growth factor (TGF)-β signalling mechanisms. Our objectives were to...

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PMID: 21737550
DOI: 10.1183/09031936.00187310

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