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Article

L55P transthyretin accelerates subunit exchange and leads to rapid formation of hybrid tetramers.

The Journal of biological chemistry - 16 Dec 2005

Keetch Catherine A, Bromley Elizabeth H C, McCammon Margaret G, Wang Nan, Christodoulou John, Robinson Carol V

Abstract excerpt

Transthyretin is a tetrameric protein associated with the commonest form of systemic amyloid disease. Using isotopically labeled proteins and mass spectrometry, we compared subunit exchange in wild-type transthyretin with that of the variant associated with the most aggressive form of the disease, L55P. Wild-type subunit exchange occurs via both monomers and dimers, whereas exchange via dimers is the dominant...

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Identifiers

PMID: 16219761
DOI: 10.1074/jbc.M508753200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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