Article

Hybrid Tetramers of Wild-Type and Amyloidogenic H88R Transthyretin Challenge the Monomer Paradigm

2026-07-17

Abstract excerpt

Hereditary transthyretin amyloidosis (ATTRv) is driven by mutations that destabilize the native tetrameric transthyretin (TTR), promoting monomer formation and amyloid aggregation. The H88R variant has been considered fully monomeric, yet its behavior in heterozygous patients has remained unclear. Here, we demonstrate that H88R TTR can form hybrid tetramers with wild-type chains, both in vitro and in patient sera....

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Literature Corpus work: 4c25128b-0025-51b6-9bae-df605710c3c6
DOI: 10.64898/2026.07.13.738148

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