Article
Th1 cytokine polymorphisms in spanish patients with type 1 diabetes.
Human immunology - 1 Aug 2005
Santiago José L, Martínez Alfonso, de La Calle Hermenegildo, Fernández-Arquero Miguel, de La Concha Emilio G, Urcelay Elena
Abstract excerpt
Several polymorphisms in regions where Th1 cytokines (IL12B and IFNG genes) are located were analyzed in 303 Spanish subjects with type 1 diabetes and compared with a control cohort (n = 548). Both groups comprised residents of the Madrid area. The haplotype frequencies were estimated by the expectation-maximization algorithm, and p values were corrected by the number of haplotypes taken into account in the...
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